All outbound lanes on Sydney Road at the turn off to the Ring Road are closed after a serious accident.
The left lane has been closed inbound, while the ramp from Sydney Rdoa to the Ring Road heading towards Greensborough has been closed.
Up to 11 cars are believed to be involved, and up to 13 people injured.
The authorities are warning people to steer clear of the area.
Channel 9 are reporting that a truck crashed into 'multiple cars’.