A woman's died in a crash on the Pacific Highway at Cams Wharf early this morning.
The 38 year old was driving north in the southbound lanes, when her Hyundai Getz collided with a Holden Commodore travelling in the opposite direction at around 2am.
The crash happened about 300m north of the Cams Wharf Road intersection.
The woman died at the scene, while the 49 year old male driver of the Commodore was taken to John Hunter Hospital suffering serious injuries.
Police are appealing for any witnesses to come forward to shed light on why she was driving on the wrong side of the road.