Mildura Police are appealing to the public for any details on missing 16 year old Nichola Kirkpatrick.
The teenager was last seen at a bus stop on Seventh Street in Mildura.
Investigators believe she may be travelling to Cootamundra in New South Wales, possibly with a male companion.
It is believed that she may have boarded a second bus to Canberra at approximately 2:50pm before arriving there at 5:40pm.
Nichola is described as 157 centimetres tall, with a medium build and blue eyes along with blonde and red hair; which is often tied back in a bun.
There are concerns for her welfare due to her age and the fact that she has a medical condition.
Anyone with information on Nicola's whereabouts is urged to call Crime Stoppers.