Forest Road is closed in both directions in Arncliffe due to a serious car crash at Pitt-Owen Avenue.
Motorists are advised to avoid the area and use the Princes Highway instead.
There is a local diversion in place for eastbound and westbound motorists already in the area.
There is also no westbound access from the Princes Highway into Forest Road.
Motorists should allow plenty of extra travel time, expect delays and follow the directions of traffic controllers.
Emergency services are at the scene working to clear it as quickly as possible.
For the latest traffic information, visit www.livetraffic.com or call 132 701.