Emergency services are currently responding to a multi-vehicle crash just over the Anzac Bridge.
Up to eight cars and a truck were involved in the crash, which happened on the western side of the bridge in Rozelle.
The incident happened just after 1pm, with three patients assessed for minor injuries.
One patient is set to be transported to hospital for further treatment.
Three westbound lanes fo Victoria Road have been closed near the Crescent, while two westbound lanes are open past the crash site.
Traffic is heavy.