Two people have died and it is estimated that at least three others remain trapped after a serious multi-vehicle crash north of Dubbo.
The incident is understood to involve a truck, with eight ambulance crews and three helicopters sent to the accident site on the Newell Highway.
A call to emergency services was placed at about 12.30pm today, and early reports suggest four cars and a truck were involved in the collision.
One car is understood to be completely crushed under the truck according to a NSW Ambulance spokesperson.
The Newell Highway is closed in both directions.
Motorists are advised to avoid the area.