Adelaide coach Don Pyke has confirmed stars Brad Crouch and Jake Lever will miss their clash with Collingwood.
Crouch has been ruled out after sustaining a fractured cheekbone against Geelong last Friday, despite playing out the game.
Lever will miss with the hamstring complaint that saw him sidelined last week.
Better news, however, comes through the returns of Kyle Hartigan and Wayne Milera, who have both reached full fitness.
Hartigan has missed three games since straining his hamstring against Carlton, while Milera has missed two games with a calf complaint.