Horror start to the Easter long weekend on our roads- Edmonton man in critical condition.

A man has been airlifted to Townsville Hospital in a critical condition after a serious car crash at Bilyana, Cassowary Coast today.

Around 3.20pm, two men, aged 41 and 42, were travelling south on the Bruce Highway when their car has crossed over into the north bound lane and collided with another car, that was towing a boat.

The 41-year-old driver received serious injuries, while the 42-year-old man who was a passenger was taken by ambulance to Tully Hospital.

The two adults and two children in the second car travelling north were not physically injured.

The Forensic Crash Unit attended the location and are conducting investigations into the crash.

Investigators are seeking anyone who witnessed the incident or who may have dash cam to contact the police.